Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. do not list duloxetine among the recommended treatment options. A review from the Annals of Internal Medicine lists duloxetine among the first line drug treatments, however, along with citalopram, escitalopram, sertraline, paroxetine, and venlafaxine. Cymbalta (Eli Lilly)30 mg and 60 mg capsules Approved indication: major depression Australian Medicines Handbook section 18.1.2 Duloxetine is a new antidepressant which selectively inhibits serotonin and noradrenaline reuptake. After oral administration of duloxetine, maximum plasma concentrations are reached after six hours. Duloxetine is extensively metabolised in the liver and has an overall half-life of about 12 hours. The efficacy of duloxetine (60 mg/day) has been compared to that of escitalopram (10 mg/day) and placebo in a randomised study of 684 patients (randomised in a 2:2:1 ratio). The onset of efficacy was defined as a 20% sustained reduction in the patient's score on the Hamilton Rating Scale for Depression Maier subscale, by the second week of treatment. The probability of meeting these criteria was 42.6% in patients given duloxetine, 35.2% in patients given escitalopram and 21.5% in patients given placebo. After eight weeks, the probability of responding to treatment (defined as a 50% improvement from baseline on the Hamilton Rating Scale for Depression) was not statistically different between patients given active drug or placebo. Response rates were 48.7% for duloxetine, 45.3% for escitalopram and 36.9% for placebo. In a review analysing efficacy data from nine duloxetine trials, the number needed to treat for a duloxetine dose of 60 mg/day or more was 6 for a response (based on the Hamilton Rating Scale for Depression), 7-9 for remission and 6-7 for a Clinical Global Impression-defined improvement by eight weeks.
Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Show More Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list. Symbal (30 mg) | Combac (40 mg) | Combac (60 mg) | Symbal -M | Dureep | Duloxit (20mg) | Symbal (60 mg) | DXT (40 mg) | Verlox (20mg) | Detine | Dulomax (20mg) | Dulot (20mg) | Sympta | Dulx (60 mg) | Neuroxetin -30 | Duloxit (40mg) | Sympta (30mg) | C -Pact | Dutin (60 mg) | DXT (60 mg) | Dulife (30mg) | Dulotrac (20mg) | Dulotin (30 mg) | Dulife (30 mg) | Duloxyl (20mg) | Dutin | Combac | Duloxee (30 mg) | Dulife (20mg) | Dutin (30 mg) Duloxetine belongs to a class of drugs known as serotonin-norepinephrine reuptake inhibitors. It is prescribed for depression, generalized anxiety disorder and for managing chronic musculoskeletal pain caused by fibromyalgia and other conditions. It is used to treat diabetic peripheral neuropathy (damage to the nerves due to diabetes). Duloxetine acts by increasing the levels of both serotonin and norepinephrine neurotransmitters in the brain, which maintains the mental balance and stops the transmission of pain signals in the brain. Duloxetine is contraindicated in patients who also take mono amino oxidase inhibitors (MAOI) drugs.
Find patient medical information for Cymbalta Oral on WebMD including its. The dosage is based on your age, medical condition and response to treatment. Certain you can tolerate the medication, the starting dose is 30 mg daily. The most common side effect when taking duloxetine was nausea. For most people.