Given the importance of kinases in human biology, and the need within the field to selectively target an enzyme, many biotechnology companies, as well as academic drug discovery centres, also need access to kinase profiling services when assessing their small molecules. Our service is available to anyone that wishes to use it, and our panel of protein kinases has now increased in size to 140. Read more Located in the MRC PPU alongside the world’s leading experts on kinases and phosphorylation, if you require any further guidance - whether new to this field or you would just like advice from another scientist - we can help you liaise with a resident expert. You can be confident that we will approach your project with professionalism and efficiency. It is for all these reasons that our customers keep coming back. One of the things that most women who are going through breast cancer treatments complain about (and being a breast cancer coach, I do hear these complaints every single day) is all of the side effects of Tamoxifen and other aromatase inhibitor drugs. Things like terrible hot flashes, joint pain, muscle pain, carpal tunnel syndrome and even trigger finger (a painful painful condition that causes the fingers or thumb to catch or lock when bent, it happens when the tendons in the finger or thumb become inflamed) are quite common side effects. A chance conversation with one of my subscribers this week led me to do some research on vitamin D because she shared with me that she was on Tamoxifen and had been recommended to take some higher-than-normal doses of vitamin D for her joint pain, and it was helping! Vitamin D3 is one of the supplements I already recommend because it has great benefits for breast health. For more information on that, Spanish researchers at the Hospital Del Mar in 2011  discovered that the bone and joint pain associated with taking aromatase inhibitors like Tamoxifen was responsible for many women discontinuing their use. They studied 290 breast cancer patients undergoing treatment with Tamoxifen or another of the aromatase inhibitor drugs. At baseline, 90% of the women had serum vitamin D levels under 30 ng/ml, which is considered a deficiency.
In this week’s issue of People, former Victoria’s Secret model Jill Goodacre opens up about her five-year battle with breast cancer and the medication she’s been on to keep the disease at bay. Goodacre, who’s married to singer and actor Harry Connick Jr., went through surgery and radiation in 2012 after a tumor was detected via sonogram, and has taken the drug tamoxifen ever since. As she approaches her five-year cancer-free mark, Goodacre says she’s looking forward to stopping tamoxifen. The medication can cause side effects, including weight gain, which Goodacre admits she’s struggled with. “I’ve always been a pretty fit person, and so to be just rounder and heavier and not to really be able to do much about it—that’s been hard,” she told People. “It’s taken a lot out of my self-confidence.” That’s a common problem among breast cancer survivors, says Nikita Shah, MD, medical director of the Cancer Risk Evaluation Program at Orlando Health UF Health Cancer Center. Shah has not treated Goodacre, but does prescribe tamoxifen to many of her own patients.) Still, tamoxifen can be lifesaving, says Dr. Shah, and for many women, its benefits outweigh its potential side effects. DCIS (ductal carcinoma in situ) is the most common form of non-invasive breast cancer and is considered stage 0 cancer. While DCIS isn’t life threatening, it increases the risk of developing invasive breast cancer later in life. DCIS usually is treated with surgery to remove the cancer -- lumpectomy in many cases. After surgery, many women have radiation therapy to reduce the risk of DCIS coming back (recurrence). If the DCIS is hormone-receptor-positive (most are), hormonal therapy also usually is recommended after surgery. Of the adjuvant hormonal therapy choices, tamoxifen has been approved the longest and is approved to treat both premenopausal and postmenopausal women. Tamoxifen comes in both pill and liquid form and is usually taken once per day.
Tamoxifen has rarely caused very serious (possibly fatal) strokes, blood clots in the lungs/legs, and cancer of the uterus. If you are taking tamoxifen to reduce the risk of breast cancer, or if your cancer is limited to the milk ducts (ductal carcinoma in situ-DCIS), then discuss the benefits and risks of taking this medication with your doctor. However, if you are taking tamoxifen to treat breast cancer, then the benefits of taking tamoxifen are greater than the risks of side effects. Get medical help right away if you develop symptoms of a stroke or blood clots in the lungs/legs, such as weakness on one side of the body, slurred speech, sudden vision changes, confusion, shortness of breath, chest pain, or calf pain/swelling. Tell your doctor right away if you develop symptoms of cancer of the uterus, such as unusual changes in your monthly period (e.g., amount or timing of bleeding), unusual vaginal discharge, or pain/pressure below your "belly button" (navel). Show More Tamoxifen is used to treat breast cancer. It is also used to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer. Tamoxifen won't work on hormone-receptor-negative breast cancer. Tamoxifen is available in two forms: a pill taken once a day (brand name: Nolvadex) or a liquid form (brand name: Soltamox). If you dislike pills or you're having trouble swallowing tamoxifen pills, Soltamox can help make it easier to stay on your treatment plan. Most doctors recommend taking tamoxifen at the same time each day. — while you are taking tamoxifen and for 2 months afterward. You should not take tamoxifen if you are breastfeeding, pregnant, trying to get pregnant, or if there is any chance that you could be pregnant. You should use an effective non-hormonal type of birth control — such as condoms, a diaphragm along with spermicide, or a non-hormonal I. Ask your doctor which type of non-hormonal birth control would be best for you. Since its approval in 1998, tamoxifen has been used to treat millions of women and men diagnosed with hormone-receptor-positive breast cancer. While an aromatase inhibitor is the first hormonal therapy medicine choice for postmenopausal women, tamoxifen is the first choice for premenopausal women and is still a good choice for postmenopausal women who can't take an aromatase inhibitor.
Find out what tamoxifen is, how you have it and other important information about taking tamoxifen for. The liquid version of tamoxifen is called Saltamox. For women at higher risk of breast cancer, drugs such as tamoxifen and raloxifene have been shown to help reduce the risk.