According to the drug classification, it refers to retinoids, which are vitamin Aderivatives. Accutane has a strong antioxidant and anti-inflammatory effect. It contributes to a significant reduction or recurrenceprevention of severe nodular acne. Accutane is highly effective in the treatment or prevention of skin condition, in which inflammatory lesions reach more than 5 mm. It is prescribed to adults, adolescents or children over 12 years of age, who do not respond to antibiotic therapy of acne. A significant decrease in the intensity of acne is noticed already during the first two to three weeks of Accutane use. This systemic retinoid also helps to alleviate such dermatological reactions, as itching, redness or skininflammation. Dosing regimen Accutane has a high affinity for fats, and is quickly absorbed in the body, when used with low-fat food. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company controls the American biotechnology company Genentech, which is a wholly owned affiliate, and the Japanese biotechnology company Chugai Pharmaceuticals, as well as the United States-based Ventana. Roche's revenues during fiscal year 2018 were 56.85 billion Swiss francs, Descendants of the founding Hoffmann and Oeri families own slightly over half of the bearer shares with voting rights (a pool of family shareholders 45%, and Maja Oeri a further 5% apart), with Swiss pharma firm Novartis owning a further third of its shares. Roche is one of the few companies increasing their dividend every year, for 2018 as the 32nd consecutive year. Founded in 1896 by Fritz Hoffmann-La Roche, the company was early on known for producing various vitamin preparations and derivatives. In 1934, it became the first company to mass-produce synthetic vitamin C, under the brand name Redoxon. In 1957 it introduced the class of tranquilizers known as benzodiazepines (with Valium and Rohypnol being the best known members).
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