Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. Tetracyclines are named for their four ("tetra-") hydrocarbon rings ("-cycl-") derivation ("-ine"). They are defined as a subclass of polyketides, having an octahydrotetracene-2-carboxamide skeleton and are known as derivatives of polycyclic naphthacene carboxamide. While all tetracyclines have a common structure, they differ from each other by the presence of chloride, methyl, and hydroxyl groups. These modifications do not change their broad antibacterial activity, but do affect pharmacological properties such as half-life and binding to proteins in serum. Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. Tetracyclines are among the cheapest classes of antibiotics available and have been used extensively in the prophylaxis and therapy of human and animal infections, as well as at subtherapeutic levels in animals feed as growth promoters. If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history. In some cases, they may not be available in every strength or form as the brand-name version.
Expired tetracycline products are known to cause Fanconi's syndrome after their expiration. This is due to epimerization and dehydration to a toxic compound. While all tetracyclines can undergo epimerization, the process of dehydration requires a hydroxyl group to be located at the C6 position. Neither minocycline nor doxycycline have a C6 hydroxyl group. This means they "cannot undergo dehydration and thus are completely free of this toxicity." (Foye's 7th ed). Disclaimer: It is recommended to discard of all old drugs after their expiration date or 1 year after being filled (whichever is earlier). One of the breakdown components is toxic, so rather than just not working well it'll both not work well AND make you sick/kill you. Disclaimer: just a tech, take with grain of salt, but in general, expired is expired, don't fuck with it. Within the Broken Arrow forums, part of the Gun Forum category; First- I'm not a doctor/pharmacist/pharmacologist/whatever. So don't blame me if you listen to my opinion and consume expired doxy. First- I'm not a doctor/pharmacist/pharmacologist/whatever. So don't blame me if you listen to my opinion and consume expired doxy. Second- I believe that antibiotics are still effective past their expiration date. Now: The long debated issue is that tetracyclines including doxycycline become toxic after its expiration date due to the compounds breaking down and producing a waste. Department of Defense Shelf Life Extension Program. I've read on a few sources that tetracyclines were redesigned so as not to produce this hazardous waste. The FDA regularly tests the DODs expired doxycycline and extends the shelf life. After quite a bit of research I have concluded that doxycycline is safe to take at any time as long as it was stored in a cool and dry environment in its original packaging or pill bottle stuffed with cotton. For doxy specifically it states anywhere from 17-133 month extensions have been granted. In my research I came across an FDA sanctioned pamphlet that addresses using doxycycline to treat anthrax exposure. At the very bottom of the 2nd page it states that if you receive doxycycline that is expired, it's okay the FDA has approved it for use. Now I understand that they are approving THEIR stock of the expired doxycycline, but if it's all stored the same way...
There have been investigations about the expiration dates on drugs. The FDA did the largest one many years ago (at the request of the military). Many drugs were found to be viable (although some perhaps a little less potent) for many years after the expiry date on the bottle. The military was asking if they had to throw away expired drugs----- and the answer was ----- no, at least for most drugs. But you can research the Wall Street Journal (March 29, 2000) for the article and make up your own mind. Of course if he's as cautious as I am for this subject with strangers or patients he'll probably say ----'don't'. (I won't give the link to the article until I hear back from Med Help's moderators about which links are 'safe' to post here. LOL) There are several drugs though that can NOT be taken after expiration. Caps for emphasis: DO NOT TAKE DOXY OR TETRACYCLINES PAST EXPIRATION. There's some research that says that may be o.k. Insulin, nitroglycerin and some liquid antibiotics are also included in the 'do not take' group. By Leigh Ann Hubbard The expiration date is not a magic number. The first two situations won’t necessarily kill you. It’s a much-discussed topic online since antibiotics aren’t like ibuprofen. The med has been tested and proven to hold up that long—if the container is unopened and stored correctly. This is one of the first things preppers (preparedness-minded people) learn when they start stockpiling. A can of vegetables that’s a while past its date may not taste as good. If they don’t work exactly right and you’re in a survival situation, it’s bad news. “It would be very unusual for a drug to have an expiration date shorter than one year or greater than five years,” Craig K. Shelf-stable products tend not to suddenly go rancid on the stamped date. Svensson, Pharm D, Ph D, dean of Purdue University’s College of Pharmacy, said via email. If the antibiotic doesn’t pull its weight, you’re at the mercy of the infection—which, thanks to that weak medicine you just took, has likely mutated into an antibiotic-resistant strain. So as a prepper, if you store antibiotics, should you immediately replace them when they’re expired? We present our findings here, to help you decide for yourself which meds to trust and for how long. S., a medication’s expiration date is like the pharmaceutical company’s guarantee: they stand by the product until that day; after that, all bets are off. ” Others say, “No, they’ll last at least a decade, if not longer! But taken together, they paint an interesting picture of what the longevity truly is—for antibiotics and many other pills. Through weeks of investigation, we uncovered both gray areas and clear facts. Like many prepper questions, this wasn’t easy to solve.
Aug 22, 2018. In April 2017, the U. S. Food and Drug Administration FDA issued draft guidance, Extending. Expiration Dates of Doxycycline Tablets and. Doxycycline expiration date cave76. There have been investigations about the expiration dates on drugs. The FDA did the largest one many years ago at the request of.