It is usually taken as a single 150 mg dose for vaginal thrush. You can take it at any time of day, either before or after a meal. Longer courses of treatment are prescribed for other types of fungal infections. However, some types of fungi can thrive and multiply on the surface of our bodies and cause infections of the skin, mouth or vagina. The most common fungi to cause skin infections are the tinea group of fungi. A common fungal infection of the mouth and vagina is called thrush. This is caused by an overgrowth of a yeast (which is a type of fungus) called . Fungal infections sometimes occur within the body also. Read the Patient Information Leaflet if available from your pharmacist before you start taking fluconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once daily. If you are taking the liquid suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. Generally in children, the dose should not exceed 600 milligrams daily unless directed by the doctor.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Oral ketoconazole was recently the subject of regulatory safety warnings because of its association with increased risk of inducing hepatic injury. However, the relative hepatotoxicity of antifungal agents has not been clearly established. The aim of this study was to compare the hepatotoxicity induced by five commonly prescribed oral antifungal agents. Rats were treated with therapeutic oral doses of griseofulvin, fluconazole, itraconazole, ketoconazole, and terbinafine. After 14 days, only ketoconazole had significantly higher ALT levels () than the control group. After 28 days, ALT levels were highest in the rats treated with ketoconazole followed by itraconazole, fluconazole, griseofulvin, and terbinafine, respectively. Access to society journal content varies across our titles. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Contact us if you experience any difficulty logging in.
Fatal instances of fluconazole induced liver injury have been reported Case 1, but most cases are self-limited, although recovery may be delayed for several. Fluconazole eg Diflucan. Fluconazole is an antifungal medicine most often used as a single dose treatment for thrush, but also prescribed in longer courses for other fungal infections.